Endocrine Abstracts

The wide range of phytochemicals in medicinal plants serves as sources of bioactive compounds for treatment diabetic complications. We investigated whether Syzygium aromaticum-isolated oleanolic acid (OA) has beneficial effects on some diabetic complications in STZ-induced diabetic rats. We used experimental models of hypertension [spontaneously hypertensive (SHR) and Dahl salt-sensitive (DSS)] rats to explore the effects of OA on mean arterial blood pressure (MAP) and renal f...

The magnitude and duration of postprandial blood glucose elevations due to hydrolysis of carbohydrates are major risk factors of diabetes and coronary heart diseases. Inhibition of the key carbohydrate hydrolyzing enzymes in the small intestine suppresses postprandial blood glucose peaks and reduces chronic vascular complications in diabetic subjects. Recent reports indicate that Syzygium spp-derived oleanolic acid (OA) inhibits glucose transport in the small intestin...

Available evidence suggests that Syzygium spp ethyl acetate solubles (EAS) contain triterpene mixtures (oleanolic/ursolic acid and methyl maslinate/methyl corosolate) with hypoglycaemic properties in streptozotocin (STZ)-induced diabetic rats. Accordingly, maslinic acid (MA) was isolated from S. aromaticum. Air-dried powdered flower buds of S. aromaticum were sequentially extracted thrice at 24 h intervals with 3 litres on each occasion of hexane, dichloromethane, ethyl acetat...